Rabbit Hole of Research the Podcast: Episode 5: Mutants! The Show Notes

This has no particular format; it’s just correcting or updating anything in the show we didn’t get a chance to fully talk about or things we had on the tips of our tongues and couldn’t get out as we recorded. As always, feel free to comment, and we will address stuff in future shows! Enjoy.

artwork by 

Georgia Geis@atomicnumber14 https://www.instagram.com/atomic_number14/

Say hello and let us know:

Who your favorite mutant is?

Favorite Cereal/food to eat while watching cartoons?

Excited about X-men 97?

What are we drinking:

Joe and Nick: Insufficient Clarence: Sketchbook Brewery

Genotype vs phenotype

Genotype is an organisms unique sequence of DNA. 

Phenotype is the observable expression of this genotype – a person’s presentation.


Hereditary mutations (germ line) vs Somatic mutations (non-germ line cells)



is a physical or chemical agent that permanently changes genetic material, usually DNA, in an organism and thus increases the frequency of mutations above the natural background level.


any substance, radionuclide, or radiation that promotes carcinogenesis (Cancer). 


substances that may cause non-heritable birth defects via a toxic effect on an embryo or fetus.


Predisposed for cancer?

Cancer from secondhand smoke.

Peppered Moth’s adaptation during Industrial Revolution

Evolutionary changes of African Elephant thank size due to poaching

Wolves adapt to radiation at Chernobyl

Marvel Unique Mutants: 


A mutant with the ability to transform her body into a pliable cloud of dust. 

Bailey Hoskins: Worst X-man ever

A mutant with the worst power of self-detonation which he could only use once, since this power could kill him

Fallout series video game

Legacy virus

The Legacy Virus was based on a virus created by Apocalypse in the distant future, which was intended to kill the remaining non-mutants.

Stryfe engineered the Legacy virus to kill mutants. In the beginning the virus was only targeting mutants but it jumped to humans

Comic series cured by Colossus and in X:Men animated series it was Wolverine was used by Cable to generate a cure (utilizing wolverine’s healing factor).

Can we create a Real Wolverine 

Healing factor 

Wolverine has healing factor: he can heal from any injury or disease. Yet, there are a number of inconstancies. Also, Wolverine has bones fused with Adamantium (a virtually indestructible steel alloy named after the fabled metal Adamantine of Greek mythology).

All about Bones:

What are Bones made of? Our bones have metal: calcium, trace metals like copper, zinc, magnesium 

Bones are needed to act as a calcium sink

Metal to Bone fusing

Osseointegration (from Latin osseus “bony” and integrare “to make whole”) is the direct structural and functional connection between living bone and the surface of a load-bearing artificial implant

Osseointegration was first observed—albeit not explicitly stated—by Bothe, Beaton, and Davenport in 1940

What happens if you coat bones in metal?

Adamantium ripped from his body by Magneto’s powers: Wolverine #75

Human genotypes/phenotypes similar Marvel’s Nightcrawler

Humans born with tails

Pointy ears

Blue skin

Fused/ Webbed fingers

Gus Gormon played by Richard Pryor in Superman III makes fake Kryptonite and creates Evil Superman.

DC doesn’t have mutants, but Metahumans. But a metahuman by any other name is still a mutant.

Godzilla clone: Space Godzilla

Movie: Gattaca (1997)

Book: Brave New World by Aldous Huxley 1932:

Hearing loss

Hair cells

Genetic hearing loss restored with gene therapy

Old age hearing loss

Alzheimer’s treatment disparities

Alzheimer’s drug trials plagued by lack of racial diversity

Movie: Rise of Planet of the Apes (2011)

Okay, that’s it for this episode. How’d we do?

You can always email (I do answer back), click the comment link below, or follow me online for real time tracking.

What’s Up Jotham?

What? Jotham has a Podcast!

Welcome! The Rabbit Hole of Research Podcast is available now! So excited to share science and pop culture with you. You can listen to the Podcast on most providers (Apple, Spotify, YouTube, Amazon, etc), the Substack app, in a browser on my website or from this email!

SubstackAppleSpotifyYouTubeAmazon, Joe’s Website

Who Are We?

We are Jotham (Joe), a research mad scientist and author; Nick, roaster of the coffee bean, entrepreneur and pop culture guru; and sometimes Georgia, librarian, storyteller, and print maker. 

So, What is this Rabbit Hole of Research Podcast? 

It’s like playing a game of Telephone, where we will start in one place and let the conversation lead us down the winding scenic road exploring the science in science fiction, separating the facts from the Handwavium. We’ll have a little fun and you’ll learn a few facts you can use to impress your friends at a party or use as a conversation starter to go down your own rabbit holes. 

It will not just be us rambling, fumbling and tumbling down the rabbit hole, but we will invite creators, thinkers and innovators on to talk about their research, creative process and join the lively conversation exploring the quirky science in fiction. 

We know you have many choices of entertainment, so we will keep the episodes short, about the time it takes to drink a tasty beverage. So, please join us on this journey down the rabbit hole.

When Can I Expect The First Episodes?


Episode 1 (Gaba Girl and Reanimation) and Episode 2 (We Talking about AI) will drop together. We should publish an episode every two weeks or so at first, but as we get into a routine we will get to weekly.

When Will The First Guests be on? And Can I Be a Guest?

So, the first guest will make an appearance in Episode 3. And sure if you want to be a guest, just drop me an email!

What About the Newsletter?

Even though I’ve been on a little Rabbit Hole of Research Newsletter vacation, don’t worry the newsletter will return this month (Feb 10th) with writing updates (like what now that my publisher closed), when will my new book go on submission to publishers, and what I’m reading, listening, watching, etc.

As always, thanks for the support! I couldn’t do this without you!


You can always email (I do answer back), click the comment link below, or follow me online for real time tracking.

Share Jotham’s Substack